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Sildenafil is used to treat male sexual perform issues (impotence or erectile dysfunction -ED). Sildenafil is administered orally for the remedy of erectile dysfunction (ED). Knowledge are limited concerning the use of sildenafil in women with neurogenic sexual dysfunction, resembling those with spinal cord damage or multiple sclerosis. The role, if any, of sildenafil within the management of sexual dysfunction in ladies remains to be established. Specific drug interplay research have not been performed with sildenafil and different platelet-aggregation inhibitors comparable to dipyridamole, ticlopidine, or clopidogrel.
In some cases, a reduction in sildenafil dosage is advisable, while in different instances, concomitant use of the medicine must be avoided. For patients requiring nitrates or nitrites for mild to moderate Viagra Générique exercise limitation, sildenafil therapy probably ought to be avoided since it is doubtless that the stress of sexual activity might precipitate an ischemic episode requiring use of the medicine for symptom relief and such combined use with sildenafil would be contraindicated.
In these studies, sildenafil improved several points of sexual operate together with frequency, firmness, and maintenance of erection; frequency of orgasm; satisfaction and pleasure of intercourse; and overall relationship satisfaction. In placebo-controlled scientific research in sufferers with ED, the drug discontinuance rate secondary to hostile results (e.g., headache, flushing, nausea) was similar for beneficial sildenafil doses (25-a hundred mg) in contrast with placebo (2.5 versus 2.three%).
Population pharmacokinetic evaluation of information from medical trials indicates that sildenafil clearance is reduced when the drug is administered concomitantly with CYP3A4 inhibitors corresponding to ketoconazole. Dizziness, which also may be related to the drug's vasodilatory effects, occurred in 2% of patients with ED receiving sildenafil in managed clinical trials.
While sildenafil is much less selective than other PDE sort 5 inhibitors (e.g., tadalafil, vardenafil), information from managed clinical trials indicate that ocular results do occur with different PDE type 5 inhibitors. Due to the excessive incidence of ED in cardiovascular patients and the general efficacy of selective PDE sort 5 inhibitors, many such patients may benefit from remedy with the drug.