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Is carvedilol better than metoprolol? It is important to note that in the COMET trial, carvedilol was compared with metoprolol tartrate. Carvedilol is a more complex, non-selective beta-blocker and may represent a more comprehensive antagonism of the characteristics of heart failure than a cardioselective beta-blocker such as metoprolol. What time of day should I take carvedilol? The extended-release capsule is usually taken once a day in the morning with food. Try to take carvedilol at around the same time (s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take carvedilol exactly as directed. Is it better to take your blood pressure medicine in the morning or at night? Some studies suggest that blood pressure pills taken at night might improve blood pressure and prevent more heart attacks and strokes than taking the same medications during the day. They also were about one-third as likely to have a heart attack or stroke or to develop heart failure, as those who took morning pills. What's the difference between lisinopril and amlodipine? Norvasc (amlodipine) and Prinivil (lisinopril) are both used to treat high blood pressure (hypertension). Norvasc and Prinivil belong to different drug classes. Norvasc is a calcium channel blocker (CCB) and Prinivil is a long-acting angiotensin converting enzyme (ACE) inhibitor. The Ashes Trevor Bayliss is still keen for Joe Root to bat at No3 in the Ashes Pre-Raphaelites Victorian Avant-Garde at the Tate Britain review Grieving Sean can still lift our spirits