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How long can you take ursodiol? Take ursodiol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. This drug must be taken for months to have an effect. You may need to take ursodiol for up to 2 years. Does ursodiol dissolve gallstones? During treatment with ursodiol for dissolution of gallstones, symptoms of biliary distress began to improve after three to six weeks. Gallstones will recur in about 50% of patients, but no consensus exists on management of patients after dissolution of their stones. What is ursodiol 300 mg used for? Uses. Ursodiol is used to dissolve certain types of gallstones, to prevent gallstones from forming in obese patients who are losing weight rapidly, and to treat a certain type of liver disease (primary biliary cirrhosis). Ursodiol is a bile acid. Russell Westbrook Traded to Rockets as a Wild N.B.A. Off-Season Continues Tunisia starts marketing 7-year euro-denominated bond Dayton holds vigil for victims of mass shooting SUV gets caught on drawbridge as it goes up